All you need to know about Vitamin B12


One of the most important B Vitamin is Vitamin B12 or Vitamin B-12.

Vitamin B12 is also know as cobalamin. It is one of the eight B vitamins.

It is a water-soluble vitamin with a key role in the normal functioning of the brain & nervous system and in the formation of blood.

Vitamain B12 is involved in the metabolism within every cell of the human body, especially affecting DNA synthesis and regulation, but also fatty acid metabolism and amino acid metabolism.

Physiological Function of Vitamin B12

Vitamin B12 is a very complex Vitamin and plays a major role in methyl group transfer and influences the normal functioning of the brain & nervous system and in the formation of blood.

Deficiency of Vitamin B12

Deficiency of Vitamin B12 occur due to

  • Inadequate dietary intake
  • Impaired absorption from lack of intrinsic factor or insufficient gastric secretions.
  • Among elderly adults due to decreased absorption of protein bound cobalamin.

Health Concerns due to Deficiency of Vitamin B12

  •  Disruption of normal Glucose and glutamic acid metabolism.
  • Increases cardiovascular risk.

Assessment of Vitamin B12 Status

Urine Methylmalonate > 3 microgram/mg creatinine

Blood Methylmalonic Acid > 0.4 Micro-mol/mL

Urine Homocysteine > 25 Micro-gram/mg Creatinine

Plasma Homocysteine > 9.8nmol/mL

Serum Vitamin B12 < 150 pg/mL

Supplementation of Vitamin B12

Adult repletion: 100 to 1,000 micro-gram/day

Best or Most Bio-available or Active form of Vitamin B12

Methylcobalamin or MB12; 5-Deoxyadenosylcobalamin (Coenzyme B12)

Dietary Sources of Vitamin B12

Dietary sources of Vitamin B12 are animal products such as fish, meat, poultry, eggs, milk, and milk product (cheese).

Anupama Singh

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